摘要 :
Dengue fever is a tropical disease caused by a virus carried by mosquitoes. The virus can cause fever,headaches, rashes, and pain throughout the body. Most cases of dengue fever are mild and go away on theirown after about a week....
展开
Dengue fever is a tropical disease caused by a virus carried by mosquitoes. The virus can cause fever,headaches, rashes, and pain throughout the body. Most cases of dengue fever are mild and go away on theirown after about a week. Dengue (DEN-gee) fever is caused by four similar viruses spread by mosquitoes of thegenus Aedes, which are common in tropical and subtropical areas worldwide. When an Aedes mosquito bites aperson who has been infected with a dengue virus, the mosquito can become a carrier of the virus. If thismosquito bites someone else, that person can be infected with dengue fever. The virus can't spread directlyfrom person to person. In rare cases, dengue fever can lead to a more serious form of the disease calleddengue hemorrhagic fever (DHF). DHF can be life threatening and needs to be treated right away.
收起
摘要 :
BACKGROUND: Dengue fever, an emerging public health issue in Pakistan bears considerable morbidity and mortality. This descriptive cross sectional study was conducted to analyze clinical, hematological and serological characterist...
展开
BACKGROUND: Dengue fever, an emerging public health issue in Pakistan bears considerable morbidity and mortality. This descriptive cross sectional study was conducted to analyze clinical, hematological and serological characteristics of dengue fever variants and to identify biomarkers that predict its severity. METHODS: 105 dengue cases (>12 years) were selected after ethical approval from Rawal Institute of Health Sciences & Benazir Bhutto Hospital Rawalpindi over 6 months (July to Dec 2015). Patients having pre-existing hematological disorder, liver disease, malaria and typhoid co-infection were excluded. Demographic data, clinical findings, hematological and serological profile documented. Patients were classified as classic dengue fever (DF), dengue hemorrhagic (DHF) and dengue shock syndrome (DSS). Data analyzed via SPSS version 17. RESULTS: Among 105 cases, there were 79(75%) males and 26(25%) females. Mean age was 30 + 12.8 years and mean duration of symptoms 5 + 2 days. Dengue fever was found in 75(75%), dengue hemorrhagic fever 24(23%) and dengue shock syndrome 2(2%). Gender, mean age and duration of symptoms were comparable between DF, DHF and DSS. Common clinical features were fever (100%), headache (56%), muscle pain (43%), vomiting (43%), retro-orbital pain (23%), bleeding (12%) and hypotension (10%). Thrombocytopenia, leukopenia and pancytopenia were frequent in DHF vs. DF. Dengue NS-1 antigen positive in 71(90%) of DF cases vs 16(57%) DHF and 1(50%) DSS. Dengue-IgM positive in 32(47%) DF vs. 19(79%) DHF and 2(100%) DSS. Dengue -IgG detected in 33(42%) DF vs. 17(71%) DHF and 1(50%) DSS. 101(96%) dengue cases were treated successfully and one case expired. CONCLUSION: Dengue-IgG and IgM are better predictive variables for dengue hemorrhagic fever as compared to NS-1 antigen that predicts classic dengue fever. Utilizing these predictive variables, imminent severe dengue may be identified and with vigilant monitoring, fluid resuscitation and pre-hand arrangement of blood products we may reduce complications and mortality in high risk cases.
收起
摘要 :
A 16-year-old female adolescent presented to the pe-diatric clinic with a history of fever that at times reached 38.3°C (101°F) and general malaise for 2 days after returning from 6 weeks abroad, where she spent time in Banglade...
展开
A 16-year-old female adolescent presented to the pe-diatric clinic with a history of fever that at times reached 38.3°C (101°F) and general malaise for 2 days after returning from 6 weeks abroad, where she spent time in Bangladesh and Saudi Arabia. Before traveling, the patient and her siblings were seen in the clinic for travel advice, and malaria prophylaxis was prescribed according to Centers for Disease Control and Prevention (CDC) guidelines. The patient disclosed that she did not take the Malarone as prescribed and thought she may have taken only two doses. Nausea and abdominal discomfort prompted her to stop taking the malaria prophylaxis. While traveling, she received multiple mosquito bites, and when visiting a relative's farm in Bangladesh, she played with cows, goats, and ducks. She presented to the clinic with a report of fever, headache, body ache, and an itchy rash on her hands.
收起
摘要 :
В обзоре на примерах завезенных случаев лихорадки Денге проанализированы основные эпидемиологические и клинические аспекты...
展开
В обзоре на примерах завезенных случаев лихорадки Денге проанализированы основные эпидемиологические и клинические аспекты болезни. Даны алгоритмы обследования больных с лихорадкой неясной этиологии, прибывших из тропических стран. На основании обширных данных литературы и международных рекомендаций представлены алгоритмы тактики лечения амбулаторных и стационарных больных лихорадкой Денге. Проанализированы перспективные исследования вакцинопрофилактики лихорадки Денге.
收起
摘要 :
? JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND| 2019Objective: To study the kinetics of endocrine changes in adult patients with dengue hemorrhagic fever (DHF) and dengue fever (DF) and association to disease severity. Materials...
展开
? JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND| 2019Objective: To study the kinetics of endocrine changes in adult patients with dengue hemorrhagic fever (DHF) and dengue fever (DF) and association to disease severity. Materials and Methods: This hospital-based observational clinical study involved 48 adult patients, 32 with DHF and 16 with DF, who presented with clinical features and positive serological testing for dengue infection on the day of diagnosis (D1). Serial circulating ACTH and cortisol concentrations were determined on D1, day of defervescence (Ddef), day 1 of convalescence (DC1 or 24 h after Ddef), day 2 of convalescence (DC2 or 48 h after Ddef), at 2-week follow-up (F1), and 2-month follow-up (F2). Results: The median cortisol concentration in the DHF group was higher on D1 than that at F2. This was not found in patients with DF who had no difference of median cortisol concentration at D1 and F2. The median ACTH concentrations in both DHF and DF groups were low on D1 and trended toward recovery at F2. There was association between circulating ACTH and cortisol concentrations at D1 in patients with the severity of DHF (r = 0.309, p = 0.042) but not of DF. Conclusion: The ACTH and cortisol responses were associated with severity of dengue infection and recovery after 2 months.
收起
摘要 :
Background and purpose: Dengue fever (DF) is a major public health issue. However, it is unclear whether different dengue virus serotypes (DENV) are associated with different clinical manifestations and outcomes. This study invest...
展开
Background and purpose: Dengue fever (DF) is a major public health issue. However, it is unclear whether different dengue virus serotypes (DENV) are associated with different clinical manifestations and outcomes. This study investigated the association between viral serotype and clinical manifestations of DF. Methods: Adult patients with DENV-2 and DENV-3 who were treated at Kaohsiung Medical University Hospital and Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan, from January 1998 to September 2007 were enrolled. The patients' demographic data, underlying diseases, clinical manifestations, laboratory data, and disease outcomes were retrospectively analyzed. Results: 294 patients had DENV-2 and 91 had DENV-3. The median age was 50 years, and 45.7% of patients were men. Patients with DENV-3 were more likely to have a malignancy (p = 0.011), myalgia (p = 0.03), skin rash (p < 0.001), ascites (p = 0.04), and fever (p = 0.003) than patients with DENV-2. Patients with DENV-3 had their lowest levels of white blood cells and platelets, and peak plasma activated partial thromboplastin time (aPTT) 1 day later than patients with DENV-2. DENV-2 infection was associated with a higher monocyte count and more prolonged aPTT early in the clinical course. Infection by DENV-2 more commonly occurred as a secondary infection, while infection by DENV-3 was more common as a primary infection (p < 0.001). There were no differences between the groups in organ involvement, disease severity, duration of hospital stay, and medical expenditure. Conclusion: The symptoms, signs, and laboratory findings appear to be different for patients infected with DENV-2 and DENV-3, but there is no difference in outcomes.
收起
摘要 :
The loss of the endothelium barrier and vascular leakage play a central role in the pathogenesis of hemorrhagic fever viruses. This can be caused either directly by the viral infection and damage of the vascular endothelium, or in...
展开
The loss of the endothelium barrier and vascular leakage play a central role in the pathogenesis of hemorrhagic fever viruses. This can be caused either directly by the viral infection and damage of the vascular endothelium, or indirectly by a dysregulated immune response resulting in an excessive activation of the endothelium. This article briefly reviews our knowledge of the importance of the disruption of the vascular endothelial barrier in two severe disease syndromes, dengue hemorrhagic fever and hantavirus pulmonary syndrome. Both viruses cause changes in vascular permeability without damaging the endothelium. Here we focus on our understanding of the virus interaction with the endothelium, the role of the endothelium in the induced pathogenesis, and the possible mechanisms by which each virus causes vascular leakage. Understanding the dynamics between viral infection and the dysregulation of the endothelial cell barrier will help us to define potential therapeutic targets for reducing disease severity.
收起
摘要 :
The numbers of patients with dengue fever are increasing in the world and affecting the health of society. Overcrowding urbanization and increase in travelling are having a direct impact on the improvement in the numbers of patien...
展开
The numbers of patients with dengue fever are increasing in the world and affecting the health of society. Overcrowding urbanization and increase in travelling are having a direct impact on the improvement in the numbers of patients. The causes of relative bradycardia like Hypothyriodism, Electrolyte imbalance and structural heart disease were also having a significant impact on the health of the human. The relative importance of immune and neural mechanisms and also any direct cardiac pathology in the aetiology of dengue associated with relative bradycardia.The researcher was conducted from July 2018 to December 2020. The researcher has selected the sample size of 100 patients from tertiary care hospital which was attached to the research institution. Most of the patients were having a history of fever and symptoms like vomiting, joint pain, diarrhoea, abdominal pain and headache.The analysis of collected data of patients shows that 98 people were having a high fever, 43 were facing issues related to vomiting, 11 patients were having malaise and 12 patients were having body ache. These symptoms have shown that dengue is affecting health and leading to relative bradycardia. The lack of treatment and delay in the care services and support can be life-threatening for the patients.The relative bradycardia is a notable feature among the patients of dengue and affecting the respiratory and heart rate of the patients. However, this condition is reported among the positive dengue IgM/NS patients. The proper investigation of the relative bradycardia situation among the patients is beneficial for the care professional to identify the method of treatment and providing clinical care.
收起
摘要 :
Dengue is a mosquito-transmitted infection that poses significant global health risks for travelers and individuals living in the tropics and subtropics. The reported global incidence has increased dramatically in the past century...
展开
Dengue is a mosquito-transmitted infection that poses significant global health risks for travelers and individuals living in the tropics and subtropics. The reported global incidence has increased dramatically in the past century, with dengue now ranking as the most common cause of febrile illness in travelers. While sporadic cases have been reported within the southern United States since 1980, autochthonous outbreaks have now been described in Hawaii, St. Croix (US Virgin Islands), along the Texas-Mexico border, and, most recently, in Key West, Florida. Although many infections are mild or asymptomatic, 5-10% of patients may experience hemorrhagic disease, with shock and even death. Laboratory identification commonly involves serologic and nucleic acid amplification methods. Due to rising incidence worldwide, physicians should be familiar with the clinical manifestations, laboratory diagnosis, and management of this illness.
收起
摘要 :
Background: The burden of dengue is high in the Philippines but the prevalence of confirmed cases is unknown, and the disease is subject to underreporting because surveillance of suspected cases is passive. We conducted a prospect...
展开
Background: The burden of dengue is high in the Philippines but the prevalence of confirmed cases is unknown, and the disease is subject to underreporting because surveillance of suspected cases is passive. We conducted a prospective epidemiological study to estimate the proportion of laboratory-confirmed dengue among clinically suspected hospitalized cases in the pediatric wards of 3 regional hospitals in the Philippines and to describe the clinical and laboratory features, age distributions, case fatality rates and serotype distributions of these hospitalized cases.
收起
原文获取